Thymosin Alpha-1 10mg
Thymosin Alpha-1, commonly abbreviated as TĪ±1 or TA-1 and also known as thymalfasin, is a synthetic 28-amino-acid peptide corresponding to the naturally occurring N-terminal region of prothymosin alpha. The peptide was originally isolated from thymic tissue and has been extensively investigated in laboratory models involving immune regulation, dendritic-cell biology, antigen presentation, T-lymphocyte signaling, and communication between innate and adaptive immune systems.
Thymosin Alpha-1 is an N-terminally acetylated, highly acidic peptide with an approximate molecular weight of 3,108 Da. Its biological activity has been examined across in vitro systems, preclinical models, and clinical research. The compound is generally characterized as an immune-modulating peptide because experimental findings indicate that its observed effects may vary according to cell type, receptor environment, immune state, and surrounding signaling conditions.
In controlled research environments, Thymosin Alpha-1 has been evaluated for its interactions with dendritic cells, monocytes, macrophages, natural killer cells, and multiple T-lymphocyte populations. Laboratory studies have examined its influence on dendritic-cell differentiation and maturation, antigen-presenting capacity, T-cell activation, cytokine production, immune-synapse signaling, and cellular responses to experimentally introduced antigens or inflammatory stimuli.
Research has also investigated Thymosin Alpha-1 in connection with Toll-like-receptor signaling. Experimental models have reported interactions involving TLR2, TLR9, and associated downstream pathways, including NF-ĪŗB and mitogen-activated protein kinase signaling. These pathways participate in microbial recognition, inflammatory regulation, cytokine production, dendritic-cell activity, and coordination between innate and adaptive immune responses.
Additional investigational areas include CD4+ and CD8+ T-cell responses, regulatory T-cell biology, natural-killer-cell activity, major histocompatibility complex expression, immune-exhaustion markers, programmed cell-death signaling, oxidative stress, and restoration of immune balance in experimentally altered systems. These findings remain dependent upon the specific model and should not be interpreted as evidence of a therapeutic effect.
Supplied in a 10 mg lyophilized presentation, Thymosin Alpha-1 is suitable for analytical and investigational laboratory workflows involving peptide characterization, receptor-associated signaling, immunology, and cellular-response research. Each vial is provided as a white to off-white lyophilized powder with a specified purity of ≥99%. Third-party certificates of analysis are published on our Lab Results page for tested compounds and added as testing is completed.
Structural Characteristics
Thymosin Alpha-1 consists of 28 amino-acid residues and includes an acetylated N-terminus. It corresponds to the first 28 amino acids of prothymosin alpha.
Amino-Acid Sequence:
Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn
- Peptide Length: 28 amino acids
- Approximate Molecular Weight: 3,108 Da
- N-Terminus: Acetylated
- General Characterization: Highly acidic peptide
- Related Precursor: Prothymosin alpha
Research Areas of Interest
- Dendritic-cell differentiation and functional maturation
- Antigen processing and presentation
- Innate and adaptive immune-system communication
- CD4+ and CD8+ T-lymphocyte signaling
- Natural-killer-cell and macrophage activity
- Toll-like-receptor-associated signaling
- TLR2, TLR9, NF-ĪŗB, and MAPK pathway research
- Cytokine and chemokine regulation
- Immune-synapse formation and cellular communication
- Major histocompatibility complex expression
- Regulatory T-cell and immune-tolerance models
- Programmed cell-death and immune-exhaustion signaling
- Cellular responses to inflammatory or antigenic stimuli
- Immune restoration and homeostasis models
Experimental findings involving Thymosin Alpha-1 may vary substantially between isolated-cell systems, animal models, and clinical research. Observed activity can depend upon the cell population, signaling environment, experimental concentration, duration of exposure, and immune model under investigation.
Specifications
Size: 10 mg
Compound Type: Synthetic N-terminally acetylated peptide
Peptide Length: 28 amino acids
Alternative Names: Thymosin Alpha-1, TĪ±1, TA-1, Thymalfasin
Approximate Molecular Weight: 3,108 Da
Form: Lyophilized powder
Appearance: White to off-white lyophilized material
Purity: ≥99% (target specification)
Storage: Store at -20Ā°C away from light and moisture. Reconstitute only under appropriate laboratory conditions using standard research protocols.
Laboratory Handling & Safety
This material should be handled only by qualified individuals using laboratory practices appropriate for synthetic peptide research. Appropriate personal protective equipment, contamination controls, and material-handling procedures should be selected according to the intended experimental application.
Avoid unintended exposure and direct contact with skin, eyes, and mucous membranes. Prevent cross-contamination between samples and minimize unnecessary exposure to light, moisture, elevated temperatures, and repeated freeze-thaw conditions.
Before laboratory use, inspect the vial for compromised container integrity, unexpected discoloration, particulate contamination, moisture intrusion, or physical changes inconsistent with the expected lyophilized presentation.
Intended Use
This product is supplied strictly for laboratory research purposes only and is intended for use by qualified professionals in controlled scientific environments. It is not for human or animal consumption and is not intended for therapeutic, diagnostic, veterinary, cosmetic, or food use. All handling and use must comply with applicable institutional and regulatory guidelines.
Information describing experimental pathways or published investigations is provided solely for research characterization and should not be interpreted as evidence of safety, efficacy, or suitability for any medical application.
FDA Disclaimer
The statements made on this website have not been evaluated by the U.S. Food and Drug Administration (FDA). Products offered are not intended to diagnose, treat, cure, or prevent any disease. Alamo Peptides operates solely as a supplier of research materials and analytical reagents. We are not a pharmacy, outsourcing facility, or pharmaceutical manufacturer. All products are intended exclusively for research use only. By purchasing, customers acknowledge responsibility for proper handling, use, and compliance with all applicable laws and regulations.
Terms of Sale
All sales are final due to the nature of research materials. Purchasers must be 21 years of age or older. Improper use voids any warranties. Alamo Peptides assumes no liability for misuse or improper application of supplied materials.
