MOTS-c – 10 mg / 40 mg
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a research-grade synthetic 16-amino-acid mitochondrial-derived peptide (MDP) supplied as a high-purity reagent for laboratory investigations into mitochondrial-nuclear communication, metabolic homeostasis, AMPK pathway activation, and stress response mechanisms. This naturally encoded peptide serves as a powerful tool in in vitro studies exploring energy metabolism regulation, insulin sensitivity, glucose utilization, fatty acid oxidation, age-related metabolic decline, and adaptive cellular responses in controlled experimental models.
In published preclinical and mechanistic studies, MOTS-c has demonstrated translocation to the nucleus under metabolic stress conditions, where it modulates gene expression via the folate-AICAR-AMPK pathway—facilitating enhanced mitochondrial function, reduced insulin resistance, improved physical performance in aging models, and protection against metabolic dysfunction distinct from other mitochondrial signals or traditional metabolic regulators. It has been utilized in research to probe skeletal muscle metabolism, nuclear gene regulation, proteostasis, and cellular adaptation in cell culture assays, myoblast models, and in vitro systems.
Available in both 10 mg and 40 mg lyophilized presentations, MOTS-c is suitable for a range of laboratory workflows including standard exploratory studies, dose-response characterization, extended experimental protocols, metabolic pathway analyses, and larger-scale cell culture or enzymatic research applications. Each vial is supplied as a white lyophilized powder with documented purity exceeding 99% by HPLC, verified through third-party testing, and accompanied by certificates of analysis including mass spectrometry confirmation.
Specifications
- Available Quantities: 10 mg / 40 mg
- Form: Lyophilized powder
- Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular Weight: ~2174.6 g/mol
- Purity: >99% (HPLC verified)
- CAS No.: 1627580-64-6
- Storage: Keep lyophilized vial at -20°C; protect from light and moisture. Reconstitute only in qualified lab settings per standard protocols.
Intended Use
This peptide is supplied strictly for in vitro and laboratory research purposes only by qualified professionals in controlled scientific environments. It is not for human or animal consumption, not for therapeutic, diagnostic, veterinary, food, cosmetic, or any non-research applications. All handling must comply with institutional biosafety and regulatory guidelines.
Lab Demonstration
This educational video demonstrates general laboratory preparation and handling of this research material in a laboratory context. For research use only.
FDA Disclaimer
The information provided on this website has not been evaluated or approved by the U.S. Food and Drug Administration (FDA). None of the statements herein, nor any products offered, are intended to diagnose, treat, cure, mitigate, or prevent any disease or medical condition. Alamo Peptides operates solely as a chemical and research reagent supplier. We are not a compounding pharmacy, do not operate under Section 503A or 503B of the Federal Food, Drug, and Cosmetic Act, are not a pharmaceutical company, and do not conduct or support clinical trials. All products are research reagents only—not for human use. By purchasing, you confirm you are a qualified researcher and assume full responsibility for lawful handling, use, and compliance.
Terms of Sale
All sales are final due to the nature of research materials. Buyers must be 21+ and verify qualifications upon request. Misuse voids any implied warranties; Alamo Peptides assumes no liability for improper application.
For research use only by qualified professionals. Contact support@alamopeptides.com (or via Discord) for COA requests or inquiries.
